The MLCK-mediated α(1)-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCɛ signaling

1. The present study examined the role of myosin light chain kinase (MLCK), PKC isozymes, and inositol 1,4,5-trisphosphate (IP(3)) receptor in the positive inotropic effect of α(1)-adrenergic stimulation in atrial myocardium. 2. We measured inotropic effects of phenylephrine (0.3–300 μM) in isolated...

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Detalhes bibliográficos
Main Authors: Grimm, Michael, Mahnecke, Nina, Soja, Friederike, El-Armouche, Ali, Haas, Pascal, Treede, Hendrik, Reichenspurner, Hermann, Eschenhagen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751924/
https://ncbi.nlm.nih.gov/pubmed/16783412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706803
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