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Replication in mammalian cells recapitulates the locus-specific differences in somatic instability of genomic GAA triplet-repeats
Friedreich ataxia is caused by an expanded (GAA·TTC)(n) sequence in intron 1 of the FXN gene. Small pool PCR analysis showed that pure (GAA·TTC)(44+) sequences at the FXN locus are unstable in somatic cells in vivo, displaying both expansions and contractions. On searching the entire human and mouse...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1669776/ https://ncbi.nlm.nih.gov/pubmed/17142224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl846 |
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