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Large Conformational Changes in a Kinesin Motor Catalyzed by Interaction with Microtubules

Kinesin motor proteins release nucleotide upon interaction with microtubules (MTs), then bind and hydrolyze ATP to move along the MT. Although crystal structures of kinesin motors bound to nucleotides have been solved, nucleotide-free structures have not. Here, using cryomicroscopy and three-dimensi...

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Détails bibliographiques
Auteurs principaux: Hirose, Keiko, Akimaru, Erika, Akiba, Toshihiko, Endow, Sharyn A., Amos, Linda A.
Format: Artigo
Langue:Inglês
Publié: 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635653/
https://ncbi.nlm.nih.gov/pubmed/16973442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.07.020
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