Aggressive Very Low-Density Lipoprotein (VLDL) and LDL Lowering by Gene Transfer of the VLDL Receptor Combined with a Low-Fat Diet Regimen Induces Regression and Reduces Macrophage Content in Advanced Atherosclerotic Lesions in LDL Receptor-Deficient Mice

Very low-density lipoprotein (VLDL) and LDL plasma levels are associated with cardiovascular mortality. Whereas VLDL/LDL lowering causes regression of early atherosclerotic lesions, less is known about the effects of aggressive lipid lowering on regression of advanced complex lesions. We therefore i...

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Hlavní autoři: MacDougall, Erin D., Kramer, Farah, Polinsky, Patti, Barnhart, Shelley, Askari, Bardia, Johansson, Fredrik, Varon, Rebecca, Rosenfeld, Michael E., Oka, Kazuhiro, Chan, Lawrence, Schwartz, Stephen M., Bornfeldt, Karin E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2006
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606621/
https://ncbi.nlm.nih.gov/pubmed/16723719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051009
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