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Elimination of Myostatin Does Not Combat Muscular Dystrophy in dy Mice but Increases Postnatal Lethality

Myostatin is a TGF-β family member and a negative regulator of skeletal muscle growth. It has been proposed that reduction or elimination of myostatin could be a treatment for degenerative muscle diseases such as muscular dystrophy. Laminin-deficient congenital muscular dystrophy is one of the most...

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Главные авторы: Li, Zhi-fang, Shelton, G. Diane, Engvall, Eva
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602316/
https://ncbi.nlm.nih.gov/pubmed/15681832
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