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Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats

1. We used spinal microdialysis in awake rats to investigate whether the repeated withdrawal with naloxone during continuous spinal infusion of morphine would lead to a progressively greater spinal glutamate release and a more pronounced intrathecal tolerance. 2. Rats received lumbar intrathecal (IT...

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Main Authors: Ibuki, Takae, Marsala, Martin, Masuyama, Takashi, Yaksh, Tony L
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573708/
https://ncbi.nlm.nih.gov/pubmed/12598423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705102
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