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Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern

1. In this study we used cortical stimulation to assess the effects of phenytoin (PHT), sodium valproate (VPA), and their interaction on total motor seizure and on the constituent elements of the seizure. 2. PHT (40 mg kg(−1)) was administered as an intravenous bolus infusion to animals receiving ei...

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Autori principali: Paschoa, O E Della, Kruk, M R, Hamstra, R, Voskuyl, R A, Danhof, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565668/
https://ncbi.nlm.nih.gov/pubmed/9846637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702155
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