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The effect of losigamone (AO-33) on electrical activity and excitatory amino acid release in mouse cortical slices

1. Losigamone is a novel anticonvulsant the mechanism of action of which is not known. This study investigated the effect of losigamone on spontaneous, NMDA- and AMPA-induced depolarizations in the cortical wedge preparation of the DBA/2 mouse (which are susceptible to sound-induced seizures) and on...

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Detalhes bibliográficos
Main Authors: Srinivasan, Jayashri, Richens, Alan, Davies, John A
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565095/
https://ncbi.nlm.nih.gov/pubmed/9421300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701539
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