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Tolerance to μ-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5′-O-(3-[(35)S]-thio)triphosphate binding
1. The agonist action of morphine on membranes prepared from human neuroblastoma SH-SY5Y cells was measured by an increase in the binding of the GTP analogue [(35)S]-GTPγS. Morphine increased the binding of [(35)S]-GTPγS to SH-SY5Y cell membranes by 30 fmol mg(−1) protein with an EC(50) value of 76±...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1997
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564818/ https://ncbi.nlm.nih.gov/pubmed/9257923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701253 |
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