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Tolerance to μ-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5′-O-(3-[(35)S]-thio)triphosphate binding

1. The agonist action of morphine on membranes prepared from human neuroblastoma SH-SY5Y cells was measured by an increase in the binding of the GTP analogue [(35)S]-GTPγS. Morphine increased the binding of [(35)S]-GTPγS to SH-SY5Y cell membranes by 30 fmol mg(−1) protein with an EC(50) value of 76±...

詳細記述

保存先:
書誌詳細
主要な著者: Elliott, Jackie, Guo, Li, Traynor, John R
フォーマット: Artigo
言語:Inglês
出版事項: 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564818/
https://ncbi.nlm.nih.gov/pubmed/9257923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701253
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