Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels

ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation of the strong oxidant peroxynitrite. Increased oxidative stress affects the heme-containing NO receptor sGC by both decre...

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Autori principali: Stasch, Johannes-Peter, Schmidt, Peter M., Nedvetsky, Pavel I., Nedvetskaya, Tatiana Y., H.S., Arun Kumar, Meurer, Sabine, Deile, Martin, Taye, Ashraf, Knorr, Andreas, Lapp, Harald, Müller, Helmut, Turgay, Yagmur, Rothkegel, Christiane, Tersteegen, Adrian, Kemp-Harper, Barbara, Müller-Esterl, Werner, Schmidt, Harald H.H.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1555649/
https://ncbi.nlm.nih.gov/pubmed/16955146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28371
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