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Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation of the strong oxidant peroxynitrite. Increased oxidative stress affects the heme-containing NO receptor sGC by both decre...
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| Autori principali: | , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1555649/ https://ncbi.nlm.nih.gov/pubmed/16955146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28371 |
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