Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia

BACKGROUND: Hypophosphatasia (HP) is an inborn error of bone metabolism characterized by a genetic defect in the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP). There is a lack of knowledge as to how the variability and clinical severity of the HP phenotype (especially pain and w...

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Bibliographic Details
Main Authors: Girschick, HJ, Schneider, P, Haubitz, I, Hiort, O, Collmann, H, Beer, M, Shin, YS, Seyberth, HW
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Case Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533806/
https://ncbi.nlm.nih.gov/pubmed/16803637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-1-24
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