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Stat-mediated Signaling Induced by Type I and Type II Interferons (IFNs) Is Differentially Controlled through Lipid Microdomain Association and Clathrin-dependent Endocytosis of IFN Receptors

Type I (α/β) and type II (γ) interferons (IFNs) bind to distinct receptors, although they activate the same signal transducer and activator of transcription, Stat1, raising the question of how signal specificity is maintained. Here, we have characterized the sorting of IFN receptors (IFN-Rs) at the...

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Autors principals: Marchetti, Marta, Monier, Marie-Noelle, Fradagrada, Alexandre, Mitchell, Keith, Baychelier, Florence, Eid, Pierre, Johannes, Ludger, Lamaze, Christophe
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483027/
https://ncbi.nlm.nih.gov/pubmed/16624862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0076
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