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Effect of Intracellular Magnesium and Oxygen Tension on K(+)-Cl(−) Cotransport in Normal and Sickle Human Red Cells
In red cells from normal individuals (HbA cells), the K(+)-Cl(−) cotransporter (KCC) is inactivated by low O(2) tension whilst in those from sickle cell patients (HbS cells), it remains fully active. Changes in free intracellular [Mg(2+)] have been proposed as a mechanism. In HbA cells, KCC activity...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1475928/ https://ncbi.nlm.nih.gov/pubmed/16543728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000092073 |
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