The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck

Therapies that target signaling pathways critical to the pathogenesis and progression of squamous cell carcinoma of the head and neck (HNSCC) are needed. One such target, phosphatidylinositol 3-kinase, and its downstream target serine/threonine kinase, Akt, are up-regulated in HNSCC. Targeted therap...

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Hauptverfasser: Mandal, Mahitosh, Younes, Maher, Swan, Eric A., Jasser, Samar A., Doan, Dao, Yigitbasi, Orhan, McMurphey, Andrea, Ludwick, James, El-Naggar, Adel K., Bucana, Cora, Mills, Gordon B., Myers, Jeffrey N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414640/
https://ncbi.nlm.nih.gov/pubmed/16442835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2005.09.011
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