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Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
IL-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits IL-2Rα, IL-2Rβ, and γ(c). Here, we describe the crystal structure of the trimeric assembly of the human IL-2 r...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413841/ https://ncbi.nlm.nih.gov/pubmed/16477002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511161103 |
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