Nonsense-Containing mRNAs That Accumulate in the Absence of a Functional Nonsense-Mediated mRNA Decay Pathway Are Destabilized Rapidly upon Its Restitution

Nonsense-mediated mRNA decay (NMD) is a conserved proofreading mechanism that protects eukaryotic cells from the potentially deleterious effects of truncated proteins. Studies of Saccharomyces cerevisiae imply that NMD is a predominantly cytoplasmic decay pathway, while studies of mammalian systems...

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Detalles Bibliográficos
Main Authors: Maderazo, Alan B., Belk, Jonathan P., He, Feng, Jacobson, Allan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC140708/
https://ncbi.nlm.nih.gov/pubmed/12529390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.842-851.2003
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