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Induction of diabetes with islet-specific T-cell clones is age dependent.

To investigate the effects of recipient age on the induction of diabetes by CD4+ islet-specific T-cell clones, we tested four different clones in non-obese diabetic (NOD) mice of different ages. Transfer of each of the T-cell clones resulted in insulitis and full development of diabetes in unirradia...

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Main Authors: Peterson, J D, Pike, B, Dallas-Pedretti, A, Haskins, K
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383920/
https://ncbi.nlm.nih.gov/pubmed/7558135
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