A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding

FSAP (Factor VII-activating protease) is a novel plasma-derived serine protease that regulates haemostasis as well as vascular cell proliferation. FSAP undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA. Competition experiments suggest that RNA and heparin...

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Detalhes bibliográficos
Main Authors: Altincicek, Boran, Shibamiya, Aya, Trusheim, Heidi, Tzima, Eleni, Niepmann, Michael, Linder, Dietmar, Preissner, Klaus T., Kanse, Sandip M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383718/
https://ncbi.nlm.nih.gov/pubmed/16332249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051563
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