Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine.

1. The biotransformation of the triazolobenzodiazepine alprazolam (ALP) to its hydroxylated metabolites (4-OH-ALP and alpha-OH-ALP) was evaluated in human, monkey, rat, and mouse liver microsomes. 2. In all species 4-OH-ALP was the principal metabolite, accounting for 84% of clearance in human micro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: von Moltke, L L, Greenblatt, D J, Cotreau-Bibbo, M M, Harmatz, J S, Shader, R I
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364833/
https://ncbi.nlm.nih.gov/pubmed/7946933
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