Human Immunodeficiency Virus Type 1 Enters Brain Microvascular Endothelia by Macropinocytosis Dependent on Lipid Rafts and the Mitogen-Activated Protein Kinase Signaling Pathway

Brain microvascular endothelial cells (BMVECs) present an incomplete barrier to human immunodeficiency virus type 1 (HIV-1) neuroinvasion. In order to clarify the mechanisms of HIV-1 invasion, we have examined HIV-1 uptake and transcellular penetration in an in vitro BMVEC model. No evidence of prod...

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Autori principali: Liu, Nancy Q., Lossinsky, Albert S., Popik, Waldemar, Li, Xia, Gujuluva, Chandrasekhar, Kriederman, Benjamin, Roberts, Jaclyn, Pushkarsky, Tatania, Bukrinsky, Michael, Witte, Marlys, Weinand, Martin, Fiala, Milan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC136265/
https://ncbi.nlm.nih.gov/pubmed/12050382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.13.6689-6700.2002
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