Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain

Cyclo-oxygenases (COXs) catalyse the synthesis of PGH(2) (prostaglandin H(2)), which serves as the common substrate for the production of PGE(2), PGD(2), PGF(2α), prostacyclin (or PGI(2)) and TXs (thromboxanes). While COX-1 is the major isoform responsible for prostanoid synthesis in healthy tissues...

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Bibliografiske detaljer
Main Authors: Hétu, Pierre-Olivier, Riendeau, Denis
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276956/
https://ncbi.nlm.nih.gov/pubmed/16008526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050451
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