Identification of a ubiquitin–protein ligase subunit within the CCR4–NOT transcription repressor complex

The RING finger protein CNOT4 is a component of the CCR4–NOT complex. This complex is implicated in repression of RNA polymerase II transcription. Here we demonstrate that CNOT4 functions as a ubiquitin–protein ligase (E3). We show that the unique C(4)C(4) RING domain of CNOT4 interacts with a subse...

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Detalhes bibliográficos
Main Authors: Albert, Thomas K., Hanzawa, Hiroyuki, Legtenberg, Yvonne I.A., de Ruwe, Marjolein J., van den Heuvel, Fiona A.J., Collart, Martine A., Boelens, Rolf, Timmers, H.Th.Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125831/
https://ncbi.nlm.nih.gov/pubmed/11823428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.3.355
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