HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8(+) T cell responses in nonhuman primates

Induction and maintenance of antibody and T cell responses will be critical for developing a successful vaccine against HIV. A rational approach for generating such responses is to design vaccines or adjuvants that have the capacity to activate specific antigen-presenting cells. In this regard, dend...

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Autores principales: Wille-Reece, Ulrike, Flynn, Barbara J., Loré, Karin, Koup, Richard A., Kedl, Ross M., Mattapallil, Joseph J., Weiss, Walter R., Roederer, Mario, Seder, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257732/
https://ncbi.nlm.nih.gov/pubmed/16219698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507484102
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