Kinetic and stereochemical studies on novel inactivators of C-terminal amidation.

C-terminal amidation, a required post-translational modification for the bioactivation of many neuropeptides, entails sequential enzymic action by peptidylglycine alpha-mono-oxygenase (PAM, EC 1.14.17.3) and peptidylamidoglycolate lyase (PGL, EC 4.3.2.5). Here we introduce novel compounds in which a...

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Autores principales: Feng, J, Shi, J, Sirimanne, S R, Mounier-Lee, C E, May, S W
Formato: Artigo
Lenguaje:Inglês
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221280/
https://ncbi.nlm.nih.gov/pubmed/10947967
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