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Mutant Caenorhabditis Elegans RNA Polymerase II with a 20,000-Fold Reduced Sensitivity to α-Amanitin

A doubly mutant ama-1(m118m526) gene results in an RNA polymerase (Rpo) II that is unusually resistant to α-amanitin. Rpo II activity in isolated Caenorhabditis elegans cell nuclei is inhibited 50% by α-amanitin at a concentration of 150 μg/ml, making this enzyme 150 times more resistant to the toxi...

詳細記述

保存先:
書誌詳細
主要な著者: Rogalski, T. M., Golomb, M., Riddle, D. L.
フォーマット: Artigo
言語:Inglês
出版事項: 1990
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1204286/
https://ncbi.nlm.nih.gov/pubmed/2076819
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