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Mutant Caenorhabditis Elegans RNA Polymerase II with a 20,000-Fold Reduced Sensitivity to α-Amanitin
A doubly mutant ama-1(m118m526) gene results in an RNA polymerase (Rpo) II that is unusually resistant to α-amanitin. Rpo II activity in isolated Caenorhabditis elegans cell nuclei is inhibited 50% by α-amanitin at a concentration of 150 μg/ml, making this enzyme 150 times more resistant to the toxi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1990
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1204286/ https://ncbi.nlm.nih.gov/pubmed/2076819 |
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