Dopamine responsiveness is regulated by targeted sorting of D2 receptors

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradati...

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Detalhes bibliográficos
Main Authors: Bartlett, Selena E., Enquist, Johan, Hopf, Frederic W., Lee, Josephine H., Gladher, Fredrik, Kharazia, Viktor, Waldhoer, Maria, Mailliard, William S., Armstrong, Randall, Bonci, Antonello, Whistler, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183554/
https://ncbi.nlm.nih.gov/pubmed/16049099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502418102
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