Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes

Interleukin-1 (IL-1), IL-17 and tumor necrosis factor alpha (TNF-α) are the main proinflammatory cytokines implicated in cartilage breakdown by matrix metalloproteinase (MMPs) in arthritic joints. We studied the impact of an anti-neoplastic antibiotic, mithramycin, on the induction of MMPs in chondr...

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Bibliographic Details
Main Authors: Liacini, Abdelhamid, Sylvester, Judith, Li, Wen Qing, Zafarullah, Muhammad
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175029/
https://ncbi.nlm.nih.gov/pubmed/15987479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1735
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