Mycobacterial Codon Optimization Enhances Antigen Expression and Virus-Specific Immune Responses in Recombinant Mycobacterium bovis Bacille Calmette-Guérin Expressing Human Immunodeficiency Virus Type 1 Gag

Although its potential for vaccine development is already known, the introduction of recombinant human immunodeficiency virus (HIV) genes to Mycobacterium bovis bacille Calmette-Guérin (BCG) has thus far elicited only limited responses. In order to improve the expression levels, we optimized the cod...

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Autori principali: Kanekiyo, Masaru, Matsuo, Kazuhiro, Hamatake, Makiko, Hamano, Takaichi, Ohsu, Takeaki, Matsumoto, Sohkichi, Yamada, Takeshi, Yamazaki, Shudo, Hasegawa, Atsuhiko, Yamamoto, Naoki, Honda, Mitsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168777/
https://ncbi.nlm.nih.gov/pubmed/15994765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.8716-8723.2005
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