Inhibition of Stat3 activation in the endometrium prevents implantation: A nonsteroidal approach to contraception

Activation of the receptors for leukemia inhibitory factor (LIF) and IL-11 is essential for embryo attachment and decidualization in mice. Both receptors induce activation of the Stat family of signal transducers via the Jak/Stat pathway. Here, we aimed to establish whether activation of Stat3 in ma...

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Main Authors: Catalano, Rob D., Johnson, Martin H., Campbell, Elizabeth A., Charnock-Jones, D. Stephen, Smith, Stephen K., Sharkey, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150834/
https://ncbi.nlm.nih.gov/pubmed/15937114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502343102
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