Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.

Fluoride and guanosine 5'-[gamma-thio]triphosphate (GTP gamma S) both activate the hepatocyte membrane polyphosphoinositide phosphodiesterase (PPI-pde) in a concentration-dependent manner. AlCl3 enhances the fluoride effect, supporting the concept that [A1F4]- is the active species. Analysis of...

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Autori principali: Cockcroft, S, Taylor, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1987
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147575/
https://ncbi.nlm.nih.gov/pubmed/3036062
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