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Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.
Fluoride and guanosine 5'-[gamma-thio]triphosphate (GTP gamma S) both activate the hepatocyte membrane polyphosphoinositide phosphodiesterase (PPI-pde) in a concentration-dependent manner. AlCl3 enhances the fluoride effect, supporting the concept that [A1F4]- is the active species. Analysis of...
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Main Authors: | , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
1987
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1147575/ https://ncbi.nlm.nih.gov/pubmed/3036062 |
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