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Arginine-Glycine-Aspartic Acid Motif Is Critical for Human Parechovirus 1 Entry
The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal....
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC114574/ https://ncbi.nlm.nih.gov/pubmed/11559835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.20.10000-10004.2001 |
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