Arginine-Glycine-Aspartic Acid Motif Is Critical for Human Parechovirus 1 Entry

The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal....

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Bibliographic Details
Main Authors: Boonyakiat, Yingmanee, Hughes, Pamela J., Ghazi, Farideh, Stanway, Glyn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114574/
https://ncbi.nlm.nih.gov/pubmed/11559835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.20.10000-10004.2001
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