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Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons

In sympathetic neurons, C(6)-ceramide, as well as endogenous ceramides, blocks apoptosis elicited by NGF (nerve growth factor) deprivation. The mechanism(s) involved in ceramide-induced neuronal survival are poorly understood. Few direct targets for the diverse cellular effects of ceramide have been...

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Autors principals: Plummer, Greg, Perreault, Kathleen R., Holmes, Charles F. B., Posse de Chaves, Elena I.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134743/
https://ncbi.nlm.nih.gov/pubmed/15361069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040929
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