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Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER

BACKGROUND: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling are not fully known. In the present work we approached this by using two of the most popular HMM packages: SAM and HMMER. T...

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Main Authors: Wistrand, Markus, Sonnhammer, Erik LL
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1097716/
https://ncbi.nlm.nih.gov/pubmed/15831105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-6-99
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