Cartilage specific collagen activates macrophages and the alternative pathway of complement: evidence for an immunopathogenic concept of rheumatoid arthritis.

We studied the effect of human interstitial collagen types I, II, and III on serum-free cultured mouse macrophages and on the complement classical and alternative pathways in human and guinea-pig serum. Type II collagen produced a dose-dependent consumption and conversion of C3 and factor B both in...

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Hauptverfasser: Hanauske-Abel, H M, Pontz, B F, Schorlemmer, H U
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1982
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1000903/
https://ncbi.nlm.nih.gov/pubmed/7073345
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