JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate cypermethrin-induced kidney damage

Cypermethrin (CYP), a widely-used composite pyrethroid pesticide, has underlying nephrotoxic effects. To elucidate potential roles of the MAPK pathway, the Jag/Notch pathway, and miRNAs in CYP-mediated kidney lesion, Sprague-Dawley rats and glomerular mesangial cells were used in this work. Results...

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Bibliographic Details
Main Authors: Changjiang Liu, Mingzhu Wu, Jiayuan Qu, Xu Huang, Qiang Zeng, Mei Ha
Format: Artigo
Language:Inglês
Published: Elsevier 2022-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Kidney damage
CXCL16
JNK/c-Jun pathway
Jag1/Notch2/Hes1 pathway
Cypermethrin
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322004225
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