Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis

Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis (MS). In autopsy material from progressive MS patients, RGMa was found in active and chronic lesions, as well as in normal-appearing gray and w...

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Main Authors: Elena Demicheva, Yi-Fang Cui, Philip Bardwell, Stefan Barghorn, Martina Kron, Axel H. Meyer, Martin Schmidt, Björn Gerlach, Mary Leddy, Eve Barlow, Elizabeth O’Connor, Chee-Ho Choi, Lili Huang, Geertruida M. Veldman, Horea Rus, Alireza P. Shabanzadeh, Nardos G. Tassew, Philippe P. Monnier, Thomas Müller, Peter A. Calabresi, Hans Schoemaker, Bernhard K. Mueller
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-03-01
Serier:Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124715002065
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