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The methodology of calculation of sample size in “non-inferiority” comparative controlled clinical trials: a comparison of two proportions in parallel group

The absolute majority of clinical trials of generic drugs aimed to compare the therapeutic efficacy of the tested drug and the drug of an active control. It is necessary to estimate that the test drug is not less effective (or non-inferior) than the control drug. The designs of the aforementioned tr...

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Autori principali: A. A. Lyashenko, M. S. Svishcheva
Natura: Artigo
Lingua:Russo
Pubblicazione: Izdatelstvo OKI 2018-06-01
Serie:Качественная клиническая практика
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Accesso online:https://www.clinvest.ru/jour/article/view/369
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