Increased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice

The purpose of this study was to explore the potential molecular mechanisms of excess homocysteine in relation to autophagic activity in the ovarian tissue of polycystic ovarian syndrome (PCOS) with hyperandrogenism.A PCOS model was constructed using ICR mice. ELISA was used to detect the Hcy levels...

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Main Authors: Ting Li, Guogang Dong, Yani Kang, Mei Zhang, Xiaoqiang Sheng, Zhilong Wang, Yang Liu, Na Kong, Haixiang Sun
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis Group 2022-04-01
Series:Bioengineered
Assuntos:
Polycystic ovarian syndrome
homocysteine
autophagy
mTOR
androgen
Acceso en liña:https://www.tandfonline.com/doi/10.1080/21655979.2022.2066608
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