Increased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice

The purpose of this study was to explore the potential molecular mechanisms of excess homocysteine in relation to autophagic activity in the ovarian tissue of polycystic ovarian syndrome (PCOS) with hyperandrogenism.A PCOS model was constructed using ICR mice. ELISA was used to detect the Hcy levels...

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Autori principali: Ting Li, Guogang Dong, Yani Kang, Mei Zhang, Xiaoqiang Sheng, Zhilong Wang, Yang Liu, Na Kong, Haixiang Sun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2022-04-01
Serie:Bioengineered
Soggetti:
Polycystic ovarian syndrome
homocysteine
autophagy
mTOR
androgen
Accesso online:https://www.tandfonline.com/doi/10.1080/21655979.2022.2066608
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