Synthesis and Biological Evaluation of Thalidomide Derivatives as Potential Anti-Psoriasis Agents

Several thalidomide derivatives were synthesized and evaluated for their anti-inflammatory activity. Introduction of the benzyl group to the parent thalidomide is unfavorable in which 2-(1-benzyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (4a) was inactivated. However, the inhibitory activities o...

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Autors principals: Kai-Wei Tang, Zih-Chan Lin, Yeh-Long Chen, Cherng-Chyi Tzeng, Jia-You Fang, Chih-Hua Tseng
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2018-10-01
Col·lecció:International Journal of Molecular Sciences
Matèries:
thalidomide
psoriasis
tumor necrosis factor
anti-inflammatory
anti-proliferative
Accés en línia:http://www.mdpi.com/1422-0067/19/10/3061
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