Instrumental Role of Helicobacter pylori γ-Glutamyl Transpeptidase in VacA-Dependent Vacuolation in Gastric Epithelial Cells.

Helicobacter pylori causes cellular vacuolation in host cells, a cytotoxic event attributed to vacuolating cytotoxin (VacA) and the presence of permeant weak bases such as ammonia. We report here the role of γ-glutamyl transpeptidase (GGT), a constitutively expressed secretory enzyme of H. pylori, i...

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Hauptverfasser: Samantha Shi Min Ling, Lawrence Han Boon Khoo, Le-Ann Hwang, Khay Guan Yeoh, Bow Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2015-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC4482420?pdf=render
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