Chemoenzymatic Synthesis of Original Stilbene Dimers Possessing Wnt Inhibition Activity in Triple-Negative Breast Cancer Cells Using the Enzymatic Secretome of Botrytis cinerea Pers.

The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancer and triple-negative breast cancer (TNBC) in particular depend upon Wnt pathway overactivation. Despite this importance, no W...

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Main Authors: Robin Huber, Alexey Koval, Laurence Marcourt, Margaux Héritier, Sylvain Schnee, Emilie Michellod, Leonardo Scapozza, Vladimir L. Katanaev, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-04-01
Serija:Frontiers in Chemistry
Teme:
chemoenzymatic synthesis
Botrytis cinerea
enzymatic secretome
stilbene dimers
high-resolution semi-preparative HPLC
dry load introduction
Online dostop:https://www.frontiersin.org/articles/10.3389/fchem.2022.881298/full
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