Chemoenzymatic Synthesis of Original Stilbene Dimers Possessing Wnt Inhibition Activity in Triple-Negative Breast Cancer Cells Using the Enzymatic Secretome of Botrytis cinerea Pers.

The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancer and triple-negative breast cancer (TNBC) in particular depend upon Wnt pathway overactivation. Despite this importance, no W...

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Hlavní autoři: Robin Huber, Alexey Koval, Laurence Marcourt, Margaux Héritier, Sylvain Schnee, Emilie Michellod, Leonardo Scapozza, Vladimir L. Katanaev, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-04-01
Edice:Frontiers in Chemistry
Témata:
chemoenzymatic synthesis
Botrytis cinerea
enzymatic secretome
stilbene dimers
high-resolution semi-preparative HPLC
dry load introduction
On-line přístup:https://www.frontiersin.org/articles/10.3389/fchem.2022.881298/full
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