Roles of TLR7 in activation of NF-κB signaling of keratinocytes by imiquimod.

Imiquimod is known to exert its effects through Toll-like receptor 7 (TLR7) and/or TLR8, resulting in expression of proinflammatory cytokines and chemokines. Keratinocytes have not been reported to constitutively express TLR7 and TLR8, and the action of imiquimod is thought to be mediated by the ade...

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Autores principales: Zheng Jun Li, Kyung-Cheol Sohn, Dae-Kyoung Choi, Ge Shi, Dongkyun Hong, Han-Eul Lee, Kyu Uang Whang, Young Ho Lee, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3795621?pdf=render
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