A novel genetic- and cell-based tool for assessing the efficacy and toxicity of anticancer drugs in vitro

Aims: To develop an in vitro tool for assessing the efficacy and toxicity of anticancer drugs using mixed culture containing both tumor and non-tumor cells. Such in vitro tool should have high application potential in drug-screening and personalized cancer care. Methods: Fibroblasts were spiked as n...

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Main Authors: Lan Kluwe, Wei Jiang, Ina Alster, Henning Hanken
Format: Artigo
Jezik:Inglês
Izdano: Palacký University Olomouc, Faculty of Medicine and Dentistry 2016-03-01
Serija:Biomedical Papers
Teme:
drug discovery
drug specificity
digital pcr
primary culture
mixed culture
chemotherapy
drug selection
mutation
copy number variation
Online dostop:https://biomed.papers.upol.cz/artkey/bio-201601-0007_A_novel_genetic-_and_cell-based_tool_for_assessing_the_efficacy_and_toxicity_of_anticancer_drugs_in_vitro.php
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