Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression

<i>Background</i>: Irisin, a novel exercise-induced myokine, was shown to mediate beneficial effects of exercise in osteoporosis. Microgravity is a major threat to bone homeostasis of astronauts during long-term spaceflight, which results in decreased bone formation. <i>Methods<...

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Main Authors: Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu, Yu Li, Airong Qian
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-02-01
Serija:International Journal of Molecular Sciences
Teme:
irisin
simulated microgravity
osteoblast differentiation
β-catenin
bone loss
Online dostop:https://www.mdpi.com/1422-0067/21/4/1259
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